Saturday, June 17, 2006

Eating Less, Avoiding Fat May Ward Off Alzheimer's

Eating Less, Avoiding Fat May Ward Off Alzheimer's

(Ivanhoe Newswire) -- People who want to reduce their chances of getting Alzheimer's disease might want to forego both the fatty french fries and the basket of bread.

According to researchers who studied a mouse model of the disease, a calorie restricted diet based on limiting the intake of carbohydrates reduces beta-amyloid peptides in the brain. Higher beta-amyloid peptide levels are known to play a role in the plaque buildup that leads to Alzheimer's disease.

Conversely, mice fed high-calorie diets also high in saturated fat developed more beta-amyloid peptides.

Their results, continue the researchers, support other studies showing a link between diet and Alzheimer's disease.

"We hope these findings further unlock the mystery of Alzheimer's and bring hope to the millions of Americans suffering from this disease," says study author Giulio Maria Pasinetti, M.D., Ph.D., professor of psychiatry and neuroscience, and director of the Neuroinflammation Research Center at Mount Sinai School of Medicine.

SOURCE: Journal of Biological Chemistry, published June 2, 2006

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