Natural Fat Loss
Obesity, diabetes tied to fat cell protein
CLEVELAND (UPI) -- U.S. scientists suggest a protein involved in the
transfer of fat in the blood may influence how fat cells store fat
linked to obesity and diabetes.
The study, published in the Journal of Biological Chemistry, looked at
how the protein -- called cholesterol ester transfer protein, or CETP
-- is involved in the cellular storage and regulation of cholesterol
and other fats.
Richard E. Morton and Lahoucine Izem of the Cleveland Clinic say CETP
may be essential for lipid metabolism and storage in fat cells and
that fat tissue is not only an energy storage tissue but also a major
"CETP is known to shuttle different types of fat between lipoproteins
-- combinations of fat and protein that transport fats in the blood,"
Morton said in a statement. "In this study, we show that CETP also
shuttles fats inside fat cells between two separate areas and that fat
cells with reduced levels of CETP are unable to process fats
CETP deficiency disrupts storage of important fats in fat cells, which
can lead to insulin resistance -- a major contributor to diabetes --
and the abnormal release of cytokines, proteins that stimulate the
immune system, according to Morton. "This unexpected contribution of
CETP provides a new understanding of how our body stores and regulates
fats and of conditions such as obesity and diabetes," said Morton.
Copyright 2007 by United Press International
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